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Sequence and structure continuity of evolutionary importance improves protein functional site discovery and annotation
Protein functional sites control most biological processes and are important targets for drug design and protein engineering. To characterize them, the evolutionary trace (ET) ranks the relative importance of residues according to their evolutionary variations. Generally, top-ranked residues cluster...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2974822/ https://ncbi.nlm.nih.gov/pubmed/20506260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.406 |
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