Specific residues of the cytoplasmic domains of cardiac inward rectifier potassium channels are effective antifibrillatory targets

Atrial and ventricular tachyarrhythmias can be perpetuated by up-regulation of inward rectifier potassium channels. Thus, it may be beneficial to block inward rectifier channels under conditions in which their function becomes arrhythmogenic (e.g., inherited gain-of-function mutation channelopathies...

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Detalhes bibliográficos
Main Authors: Noujaim, Sami F., Stuckey, Jeanne A., Ponce-Balbuena, Daniela, Ferrer-Villada, Tania, López-Izquierdo, Angelica, Pandit, Sandeep, Calvo, Conrado J., Grzeda, Krzysztof R., Berenfeld, Omer, Sánchez Chapula, José A., Jalife, José
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2010
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974416/
https://ncbi.nlm.nih.gov/pubmed/20585026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-163246
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