Human Rhabdomyosarcomas secrete MIF that modulates metastatic behavior of tumor cells and inhibits recruitment of Cancer Associated Fibroblasts

The overexpression of macrophage migration inhibitory factor (MIF) has been observed in many tumors and is implicated in oncogenic transformation and tumor progression. MIF activates CXCR2 and CD74 receptors, and as recently reported, may also bind to the stromal-derived factor-1 (SDF-1)–binding rec...

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Main Authors: Tarnowski, Maciej, Grymula, Katarzyna, Liu, Rui, Tarnowska, Joanna, Drukala, Justyna, Ratajczak, Janina, Mitchell, Robert A., Ratajczak, Mariusz Z., Kucia, Magda
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974061/
https://ncbi.nlm.nih.gov/pubmed/20861157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-10-0288
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