Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

Using a diverse collection of small molecules generated from a variety of sources, we measured protein-binding activities of each individual compound against each of 100 diverse (sequence-unrelated) proteins using small-molecule microarrays. We also analyzed structural features, including complexity...

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Bibliografiska uppgifter
Huvudupphovsmän: Clemons, Paul A., Bodycombe, Nicole E., Carrinski, Hyman A., Wilson, J. Anthony, Shamji, Alykhan F., Wagner, Bridget K., Koehler, Angela N., Schreiber, Stuart L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2010
Ämnen:
Physical Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973913/
https://ncbi.nlm.nih.gov/pubmed/20956335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012741107
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