Prevention of diabetic nephropathy in Ins2(+/−AkitaJ) mice by the mitochondria-targeted therapy MitoQ

Mitochondrial production of ROS (reactive oxygen species) is thought to be associated with the cellular damage resulting from chronic exposure to high glucose in long-term diabetic patients. We hypothesized that a mitochondria-targeted antioxidant would prevent kidney damage in the Ins2(+/−AkitaJ) m...

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Bibliografiska uppgifter
Huvudupphovsmän: Chacko, Balu K., Reily, Colin, Srivastava, Anup, Johnson, Michelle S., Ye, Yaozu, Ulasova, Elena, Agarwal, Anupam, Zinn, Kurt R., Murphy, Michael P., Kalyanaraman, Balaraman, Darley-Usmar, Victor
Materialtyp: Artigo
Språk:Inglês
Publicerad: Portland Press Ltd. 2010
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973231/
https://ncbi.nlm.nih.gov/pubmed/20825366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20100308
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