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p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation
The p53 tumor suppressor is mutated in a high percentage of human tumors. However, many other tumors retain wild-type (wt) p53 expression, raising the intriguing possibility that they actually benefit from it. Recent studies imply a role for p53 in regulation of autophagy, a catabolic pathway by whi...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2972967/ https://ncbi.nlm.nih.gov/pubmed/20937856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006124107 |
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