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LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis
Autophagy, a critical process for bulk degradation of proteins and organelles, requires conjugation of Atg8 proteins to phosphatidylethanolamine on the autophagic membrane. At least eight different Atg8 orthologs belonging to two subfamilies (LC3 and GATE-16/GABARAP) occur in mammalian cells, but th...
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| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Publishing Group
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2885923/ https://ncbi.nlm.nih.gov/pubmed/20418806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.74 |
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