LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

Autophagy, a critical process for bulk degradation of proteins and organelles, requires conjugation of Atg8 proteins to phosphatidylethanolamine on the autophagic membrane. At least eight different Atg8 orthologs belonging to two subfamilies (LC3 and GATE-16/GABARAP) occur in mammalian cells, but th...

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Bibliographische Detailangaben
Hauptverfasser: Weidberg, Hilla, Shvets, Elena, Shpilka, Tomer, Shimron, Frida, Shinder, Vera, Elazar, Zvulun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885923/
https://ncbi.nlm.nih.gov/pubmed/20418806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.74
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