LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

Autophagy, a critical process for bulk degradation of proteins and organelles, requires conjugation of Atg8 proteins to phosphatidylethanolamine on the autophagic membrane. At least eight different Atg8 orthologs belonging to two subfamilies (LC3 and GATE-16/GABARAP) occur in mammalian cells, but th...

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Main Authors: Weidberg, Hilla, Shvets, Elena, Shpilka, Tomer, Shimron, Frida, Shinder, Vera, Elazar, Zvulun
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885923/
https://ncbi.nlm.nih.gov/pubmed/20418806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.74
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