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LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis
Autophagy, a critical process for bulk degradation of proteins and organelles, requires conjugation of Atg8 proteins to phosphatidylethanolamine on the autophagic membrane. At least eight different Atg8 orthologs belonging to two subfamilies (LC3 and GATE-16/GABARAP) occur in mammalian cells, but th...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2885923/ https://ncbi.nlm.nih.gov/pubmed/20418806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.74 |
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