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The distribution of repressive histone modifications on silenced FMR1 alleles provides clues to the mechanism of gene silencing in fragile X syndrome
Fragile X syndrome (FXS) is the most common heritable cause of intellectual disability and the most common known cause of autism. Most cases of FXS result from the expansion of a CGG·CCG repeat in the 5′ UTR of the FMR1 gene that leads to gene silencing. It has previously been shown that silenced al...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2972696/ https://ncbi.nlm.nih.gov/pubmed/20843831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq394 |
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