TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections

AIMS: Transforming growth factor-β (TGF-β) signaling is critical for the differentiation of smooth muscle cells (SMCs) into quiescent cells expressing a full repertoire of contractile proteins. Heterozygous mutations in TGF-β receptor type II (TGFBR2) disrupt TGF-β signaling and lead to genetic cond...

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Detalhes bibliográficos
Main Authors: Inamoto, Sakiko, Kwartler, Callie S., Lafont, Andrea L., Liang, Yao Yun, Fadulu, Van Tran, Duraisamy, Senthil, Willing, Marcia, Estrera, Anthony, Safi, Hazim, Hannibal, Mark C., Carey, John, Wiktorowicz, John, Tan, Filemon K., Feng, Xin-Hua, Pannu, Hariyadarshi, Milewicz, Dianna M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972687/
https://ncbi.nlm.nih.gov/pubmed/20628007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq230
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