TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections

AIMS: Transforming growth factor-β (TGF-β) signaling is critical for the differentiation of smooth muscle cells (SMCs) into quiescent cells expressing a full repertoire of contractile proteins. Heterozygous mutations in TGF-β receptor type II (TGFBR2) disrupt TGF-β signaling and lead to genetic cond...

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Autors principals: Inamoto, Sakiko, Kwartler, Callie S., Lafont, Andrea L., Liang, Yao Yun, Fadulu, Van Tran, Duraisamy, Senthil, Willing, Marcia, Estrera, Anthony, Safi, Hazim, Hannibal, Mark C., Carey, John, Wiktorowicz, John, Tan, Filemon K., Feng, Xin-Hua, Pannu, Hariyadarshi, Milewicz, Dianna M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972687/
https://ncbi.nlm.nih.gov/pubmed/20628007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq230
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