TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections

AIMS: Transforming growth factor-β (TGF-β) signaling is critical for the differentiation of smooth muscle cells (SMCs) into quiescent cells expressing a full repertoire of contractile proteins. Heterozygous mutations in TGF-β receptor type II (TGFBR2) disrupt TGF-β signaling and lead to genetic cond...

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Bibliographische Detailangaben
Hauptverfasser: Inamoto, Sakiko, Kwartler, Callie S., Lafont, Andrea L., Liang, Yao Yun, Fadulu, Van Tran, Duraisamy, Senthil, Willing, Marcia, Estrera, Anthony, Safi, Hazim, Hannibal, Mark C., Carey, John, Wiktorowicz, John, Tan, Filemon K., Feng, Xin-Hua, Pannu, Hariyadarshi, Milewicz, Dianna M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972687/
https://ncbi.nlm.nih.gov/pubmed/20628007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq230
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