Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation

AIMS: Thrombospondin-1 (TSP1), via its necessary receptor CD47, inhibits nitric oxide (NO)-stimulated soluble guanylate cyclase activation in vascular smooth muscle cells, and TSP1-null mice have increased shear-dependent blood flow compared with wild-type mice. Yet, the endothelial basement membran...

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Detalhes bibliográficos
Main Authors: Bauer, Eileen M., Qin, Yan, Miller, Thomas W., Bandle, Russell W., Csanyi, Gabor, Pagano, Patrick J., Bauer, Philip M., Schnermann, Jurgen, Roberts, David D., Isenberg, Jeff S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972685/
https://ncbi.nlm.nih.gov/pubmed/20610415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq218
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