Genetic deficiency of Syk protects mice from autoantibody-induced arthritis

OBJECTIVE: The Syk tyrosine kinase plays an important role in diverse functions in hematopoietic lineage cells. Although previous in vitro and pharmacologic analyses suggested Syk to be a possible player in the development of autoimmune arthritis, no in vivo genetic studies addressing that issue hav...

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Bibliographic Details
Main Authors: Jakus, Zoltán, Simon, Edina, Balázs, Bálint, Mócsai, Attila
Format: Artigo
Language:Inglês
Published: Wiley Subscription Services, Inc., A Wiley Company 2010
Subjects:
Experimental Arthritis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972644/
https://ncbi.nlm.nih.gov/pubmed/20201079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27438
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