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Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein

Clustered damages are formed in DNA by ionising radiation and radiomimetic anticancer agents and are thought to be biologically severe. 7,8-dihydro-8-oxoguanine (8-oxoG), a major DNA damage resulting from oxidative attack, is highly mutagenic leading to a high level of G·C→T·A transversions if not p...

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Publicat a:Nucleic Acids Res
Autors principals: David-Cordonnier, Marie-Hélène, Boiteux, Serge, O’Neill, Peter
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2001
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29723/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11222760/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.5.1107
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