Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein
Clustered damages are formed in DNA by ionising radiation and radiomimetic anticancer agents and are thought to be biologically severe. 7,8-dihydro-8-oxoguanine (8-oxoG), a major DNA damage resulting from oxidative attack, is highly mutagenic leading to a high level of G·C→T·A transversions if not p...
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| Опубликовано в:: | Nucleic Acids Res |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29723/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11222760/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.5.1107 |
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