Positive and Negative Transcriptional Regulation of the Foxp3 gene is Mediated by TGF-β Signal Transducer Smad3 Access and Binding to Enhancer I

The molecular mechanisms underlying retinoic acid (RA) augmentation of T cell receptor (TCR) and transforming growth factor-β (TGF-β)-induced Foxp3 transcription and inhibition of the latter by cytokines such as IL-27 were here shown to be related processes involving modifications of baseline (TGF-β...

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Bibliographic Details
Main Authors: Xu, Lili, Kitani, Atsushi, Stuelten, Christina, McGrady, George, Fuss, Ivan, Strober, Warren
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972198/
https://ncbi.nlm.nih.gov/pubmed/20870174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.09.001
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