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Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions

Sphingosine-1-phosphate (S1P) is now emerging as a potent lipid mediator produced by mast cells that contributes to inflammatory and allergic responses. In contrast to its weak effect on degranulation of murine mast cells, S1P potently induced degranulation of the human LAD2 mast-cell line and cord...

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Hlavní autoři: Oskeritzian, Carole A., Alvarez, Sergio E., Hait, Nitai C., Price, Megan M., Milstien, Sheldon, Spiegel, Sarah
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2971746/
https://ncbi.nlm.nih.gov/pubmed/18178871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-115451
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