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Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson’s disease
Pharmacologic or genetic blockade of metabotropic glutamate mGlu5 receptors (mGluR5) has been shown to attenuate parkinsonian motor deficits and protect nigrostriatal neurons from damage in the acute MPTP model of Parkinson’s disease (PD), suggesting that therapeutically targeting the mGluR5 recepto...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2970925/ https://ncbi.nlm.nih.gov/pubmed/20854878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2010.09.043 |
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