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Effect of Glutathione S-Transferase T1, M1, P1 and Heme Oxygenase-1 Polymorphisms Interactions with Heavy Smoking on the Risk of Rheumatoid Arthritis

OBJECTIVE: Glutathione S-transferase (GST) and heme oxygenase-1 (HMOX1) genes encode enzymes that detoxify carcinogens and protect against oxidative stress. We studied gene-smoking interactions on rheumatoid arthritis (RA) susceptibility. METHODS: 549 matched Caucasian RA cases and controls were sel...

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Main Authors: Keenan, Brendan T., Chibnik, Lori B., Cui, Jing, Ding, Bo, Padyukov, Leonid, Kallberg, Henrik, Bengtsson, Camilla, Klareskog, Lars, Alfredsson, Lars, Karlson, Elizabeth W.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970699/
https://ncbi.nlm.nih.gov/pubmed/20597111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27639
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