The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

The endocannabinoid 2-arachidonoylglycerol (2-AG) regulates neurotransmission and neuroinflammation by activating CB(1) cannabinoid receptors on neurons and CB(2) cannabinoid receptors on microglia. Enzymes that hydrolyze 2-AG, such as monoacylglycerol lipase, regulate the accumulation and efficacy...

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Autori principali: Marrs, William R, Blankman, Jacqueline L, Horne, Eric A, Thomazeau, Aurore, Lin, Yi Hsing, Coy, Jonathan, Bodor, Agnes L, Muccioli, Giulio G, Hu, Sherry Shu-Jung, Woodruff, Grace, Fung, Susan, Lafourcade, Mathieu, Alexander, Jessica P, Long, Jonathan Z, Li, Weiwei, Xu, Cong, Möller, Thomas, Mackie, Ken, Manzoni, Olivier J, Cravatt, Benjamin F, Stella, Nephi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970523/
https://ncbi.nlm.nih.gov/pubmed/20657592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2601
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