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Defining the Role of Hypoxia-Inducible Factor 1 in Cancer Biology and Therapeutics
Adaptation of cancer cells to their microenvironment is an important driving force in the clonal selection that leads to invasive and metastatic disease. O(2) concentrations are markedly reduced in many human cancers compared to normal tissue and a major mechanism mediating adaptive responses to red...
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2969168/ https://ncbi.nlm.nih.gov/pubmed/19946328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.441 |
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