Feedback inhibition of aldose reductase gene expression in rat renal medulla. Galactitol accumulation reduces enzyme mRNA levels and depletes cellular inositol content.

Aldose reductase (AR) is an enzyme responsible for converting glucose into sorbitol and galactose into galactitol. In the renal inner medulla, where sorbitol production plays a role in cellular osmoregulation, AR gene expression has been shown to be osmotically regulated. The present study examined...

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I whakaputaina i:	J Clin Invest
Ngā kaituhi matua:	Bondy, C, Cowley, B D, Lightman, S L, Kador, P F
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	American Society for Clinical Investigation 1990
Ngā marau:	Research Article
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296838/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2120282/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114814
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