Feedback inhibition of aldose reductase gene expression in rat renal medulla. Galactitol accumulation reduces enzyme mRNA levels and depletes cellular inositol content.

Aldose reductase (AR) is an enzyme responsible for converting glucose into sorbitol and galactose into galactitol. In the renal inner medulla, where sorbitol production plays a role in cellular osmoregulation, AR gene expression has been shown to be osmotically regulated. The present study examined...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Bondy, C, Cowley, B D, Lightman, S L, Kador, P F
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1990
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296838/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2120282/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114814
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge