Endogenous prostaglandin endoperoxides and prostacyclin modulate the thrombolytic activity of tissue plasminogen activator. Effects of simultaneous inhibition of thromboxane A2 synthase and blockade of thromboxane A2/prostaglandin H2 receptors in a canine model of coronary thrombosis.

We tested the hypothesis that simultaneous inhibition of TxA2 synthase and blockade of TxA2/PHG2 receptors is more effective in enhancing thrombolysis and preventing reocclusion after discontinuation of tissue plasminogen activator (t-PA) than either intervention alone. Coronary thrombosis was induc...

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Pubblicato in:	J Clin Invest
Autori principali:	Golino, P, Rosolowsky, M, Yao, S K, McNatt, J, De Clerck, F, Buja, L M, Willerson, J T
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296837/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2145320/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114813
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