Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism.

Homocystinuria due to homozygous cystathionine beta-synthase deficiency is an inborn error of metabolism characterized by a high incidence of thrombosis and premature atherosclerosis. We evaluated TXA2 biosynthesis in vivo and several in vitro tests of platelet function in 11 homocystinuric patients...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Di Minno, G, Davì, G, Margaglione, M, Cirillo, F, Grandone, E, Ciabattoni, G, Catalano, I, Strisciuglio, P, Andria, G, Patrono, C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288283/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8376592/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116715
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