Congenital hypothyroidism, as studied in rats. Crucial role of maternal thyroxine but not of 3,5,3'-triiodothyronine in the protection of the fetal brain.

To study the protective effects of maternal thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in congenital hypothyroidism, we gave pregnant rats methimazole (MMI), an antithyroid drug that crosses the placenta, and infused them with three different doses of T4 or T3. The concentrations of both T...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Calvo, R, Obregón, M J, Ruiz de Oña, C, Escobar del Rey, F, Morreale de Escobar, G
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1990
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296808/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2394838/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114790
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