Immunogenicity and Protective Efficacy in Mice and Hamsters of a β-Propiolactone Inactivated Whole Virus SARS-CoV Vaccine

The immunogenicity and efficacy of β-propiolactone (BPL) inactivated whole virion SARS-CoV (WI-SARS) vaccine was evaluated in BALB/c mice and golden Syrian hamsters. The vaccine preparation was tested with or without adjuvants. Adjuvant Systems AS01(B) and AS03(A) were selected and tested for their...

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Autors principals: Roberts, Anjeanette, Lamirande, Elaine W., Vogel, Leatrice, Baras, Benoît, Goossens, Geneviève, Knott, Isabelle, Chen, Jun, Ward, Jerrold M., Vassilev, Ventzislav, Subbarao, Kanta
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2010
Matèries:
Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967819/
https://ncbi.nlm.nih.gov/pubmed/20883165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/vim.2010.0028
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