Activation of LKB1-Akt pathway independent of PI3 Kinase plays a critical role in the proliferation of hepatocellular carcinoma from NASH

LKB1, originally considered as a tumor suppressor, plays an important role in hepatocyte proliferation and liver regeneration. Mice lacking Methionine adenosyltransferase 1A (MAT1A-KO mice) gene show chronic reduction in hepatic SAMe levels, basal activation of LKB1 and spontaneously develop non-alc...

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Hlavní autoři: Martínez-López, Nuria, Varela-Rey, Marta, Fernández-Ramos, David, Woodhoo, Ashwin, Vázquez-Chantada, Mercedes, Embade, Nieves, Espinosa-Hevia, Luis, Bustamante, Francisco Javier, Parada, Luis A, Rodriguez, Manuel S, Lu, Shelly C, Mato, José M, Martínez-Chantar, Maria L
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967637/
https://ncbi.nlm.nih.gov/pubmed/20815019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23860
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