Two elliptocytogenic alpha I/74 variants of the spectrin alpha I domain. Spectrin Culoz (GGT----GTT; alpha I 40 Gly----Val) and spectrin Lyon (CTT----TTT; alpha I 43 Leu---Phe).

Spectrin alpha I/74 elliptocytosis results from abnormalities involving the "head" region of spectrin dimer. Increased susceptibility to trypsin enhances cleavage of the alpha spectrin chain, yielding an increased amount of the alpha I 74-kD fragment at the expense of the alpha I 80-kD parent fragme...

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Dades bibliogràfiques

Publicat a:	J Clin Invest
Autors principals:	Morlé, L, Roux, A F, Alloisio, N, Pothier, B, Starck, J, Denoroy, L, Morlé, F, Rudigoz, R C, Forget, B G, Delaunay, J
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Clinical Investigation 1990
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296759/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2384601/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114743
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