Two elliptocytogenic alpha I/74 variants of the spectrin alpha I domain. Spectrin Culoz (GGT----GTT; alpha I 40 Gly----Val) and spectrin Lyon (CTT----TTT; alpha I 43 Leu---Phe).

Spectrin alpha I/74 elliptocytosis results from abnormalities involving the "head" region of spectrin dimer. Increased susceptibility to trypsin enhances cleavage of the alpha spectrin chain, yielding an increased amount of the alpha I 74-kD fragment at the expense of the alpha I 80-kD par...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Morlé, L, Roux, A F, Alloisio, N, Pothier, B, Starck, J, Denoroy, L, Morlé, F, Rudigoz, R C, Forget, B G, Delaunay, J
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1990
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296759/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2384601/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114743
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