Effects of PKC412, nilotinib and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity: Mutant PDGFRA: PKC412, nilotinib, imatinib

BACKGROUND & AIMS: Activating mutations in platelet-derived growth factor receptor alpha (PDGFRA) have been reported in a subset of gastrointestinal stromal tumor (GIST) patients who do not express mutant stem cell factor receptor, c-KIT. The responsiveness of mutant PDGFRA-positive GIST to imat...

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Autori principali: Weisberg, Ellen, Wright, Renee D., Jiang, Jingrui, Ray, Arghya, Moreno, Daisy, Manley, Paul W., Fabbro, Doriano, Hall-Meyers, Elizabeth, Catley, Laurie, Podar, Klaus, Kung, Andrew L., Griffin, James D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967439/
https://ncbi.nlm.nih.gov/pubmed/17087936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2006.09.017
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