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Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

Propagation of venous thrombi or rethrombosis after coronary thrombolytic therapy can occur despite heparin administration. To explore potential mechanisms, we set out to determine whether clot-bound thrombin is relatively protected from inhibition by heparin-antithrombin III but susceptible to inac...

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Udgivet i:J Clin Invest
Principais autores: Weitz, J I, Hudoba, M, Massel, D, Maraganore, J, Hirsh, J
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296739/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2384594/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114723
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