Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP
The human nucleotide pool sanitization enzyme, MTH1, hydrolyzes 2-hydroxy-dATP and 8-hydroxy-dATP in addition to 8-hydroxy-dGTP. We report here that human MTH1 is highly specific for 2-hydroxy-ATP, among the cognate ribonucleoside triphosphates. The pyrophosphatase activities for 8-hydroxy-GTP, 2-hy...
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| Publicado no: | Nucleic Acids Res |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29672/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11139615/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.2.449 |
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