Protein expression analysis of chronic lymphocytic leukemia defines the effect of genetic aberrations and uncovers a correlation of CDK4, P27 and P53 with hierarchical risk

BACKGROUND: Chronic lymphocytic leukemia has a variable clinical course. Genomic aberrations identify prognostic subgroups, pointing towards distinct underlying biological mechanisms that are poorly understood. In particular it remains unclear whether the prognostic subgroups of chronic lymphocytic...

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Main Authors: Winkler, Dirk, Schneider, Christof, Zucknick, Manuela, Bögelein, Daniela, Schulze, Kerstin, Zenz, Thorsten, Mohr, Julia, Philippen, Angela, Huber, Henriette, Bühler, Andreas, Habermann, Annett, Benner, Axel, Döhner, Hartmut, Stilgenbauer, Stephan, Mertens, Daniel
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2010
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966910/
https://ncbi.nlm.nih.gov/pubmed/20713460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.025734
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