hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma

BACKGROUND: Uterine serous papillary adenocarcinoma (USPC) is a highly aggressive variant of endometrial cancer. Human immuno-conjugate molecule (hI-con1) is an antibody-like molecule targeted against tissue factor (TF), composed of two human Factor VII (fVII) as the targeting domain, fused to human...

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Bibliographische Detailangaben
Hauptverfasser: Cocco, E, Hu, Z, Richter, C E, Bellone, S, Casagrande, F, Bellone, M, Todeschini, P, Krikun, G, Silasi, D-A, Azodi, M, Schwartz, P E, Rutherford, T J, Buza, N, Pecorelli, S, Lockwood, C J, Santin, A D
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
Schlagworte:
Translational Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966612/
https://ncbi.nlm.nih.gov/pubmed/20700124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605760
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