Level of G Protein-Coupled Receptor Kinase-2 Determines Myocardial Ischemia-Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms

RATIONALE: Activation of pro-survival kinases and subsequent nitric oxide (NO) production by certain G protein-coupled receptors (GPCRs) protects myocardium in ischemia-reperfusion injury (I/R) models. GPCR signaling pathways are regulated by GPCR kinases (GRKs) and GRK2 has been shown to be a criti...

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Главные авторы: Brinks, Henriette, Boucher, Matthieu, Gao, Erhe, Chuprun, J. Kurt, Pesant, Stéphanie, Raake, Philip W., Huang, Z. Maggie, Wang, Xiaoliang, Qiu, Gang, Gumpert, Anna, Harris, David M., Eckhart, Andrea D., Most, Patrick, Koch, Walter J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966514/
https://ncbi.nlm.nih.gov/pubmed/20814022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.221010
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