TGF-β1 Induces an Age-Dependent Inflammation of Nerve Ganglia and Fibroplasia in the Prostate Gland Stroma of a Novel Transgenic Mouse

TGF-β1 is overexpressed in wound repair and in most proliferative disorders including benign prostatic hyperplasia and prostate cancer. The stromal microenvironment at these sites is reactive and typified by altered phenotype, matrix deposition, inflammatory responses, and alterations in nerve densi...

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Bibliographic Details
Main Authors: Barron, David A., Strand, Douglas W., Ressler, Steven J., Dang, Truong D., Hayward, Simon W., Yang, Feng, Ayala, Gustavo E., Ittmann, Michael, Rowley, David R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966419/
https://ncbi.nlm.nih.gov/pubmed/21060787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013751
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