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Target DNA chromatinization modulates nicking by L1 endonuclease

L1 elements are human transposons which replicate via an RNA intermediate. At least 15% of the human genome is composed of L1 sequence. An important initial step in the transposition reaction is nicking of the genomic DNA by L1 endonuclease (L1 EN). In vivo much of the genome exists in the form of c...

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Détails bibliographiques
Auteurs principaux: Cost, Gregory J., Golding, Amit, Schlissel, Mark S., Boeke, Jef D.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2001
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC29664/
https://ncbi.nlm.nih.gov/pubmed/11139628
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