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The Syntheses of Click PEG – Dexamethasone Conjugates for the Treatment of Rheumatoid Arthritis
A novel linear multifunctional polyethylene glycol (PEG)-dexamethasone (Dex) conjugate (click PEG-Dex) was synthesized using facile Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (a click reaction). Dex was conjugated to the click PEG via an acid-labile hydrazone bond to allow the drug release in...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2966310/ https://ncbi.nlm.nih.gov/pubmed/20831200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm100578c |
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