Pseudomonas aeruginosa Homoserine Lactone Activates Store-operated cAMP and Cystic Fibrosis Transmembrane Regulator-dependent Cl(−) Secretion by Human Airway Epithelia

The ubiquitous bacterium Pseudomonas aeruginosa frequently causes hospital-acquired infections. P. aeruginosa also infects the lungs of cystic fibrosis (CF) patients and secretes N-(3-oxo-dodecanoyl)-S-homoserine lactone (3O-C12) to regulate bacterial gene expression critical for P. aeruginosa persi...

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Main Authors: Schwarzer, Christian, Wong, Steven, Shi, James, Matthes, Elizabeth, Illek, Beate, Ianowski, Juan P., Arant, Ryan J., Isacoff, Ehud, Vais, Horia, Foskett, J. Kevin, Maiellaro, Isabella, Hofer, Aldebaran M., Machen, Terry E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966100/
https://ncbi.nlm.nih.gov/pubmed/20739289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167668
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