Zinc Dyshomeostasis Is Linked with the Loss of Mucolipidosis IV-associated TRPML1 Ion Channel

Chelatable zinc is important in brain function, and its homeostasis is maintained to prevent cytotoxic overload. However, certain pathologic events result in intracellular zinc accumulation in lysosomes and mitochondria. Abnormal lysosomes and mitochondria are common features of the human lysosomal...

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Bibliografiska uppgifter
Huvudupphovsmän: Eichelsdoerfer, Jonathan L., Evans, Jeffrey A., Slaugenhaupt, Susan A., Cuajungco, Math P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
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Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966043/
https://ncbi.nlm.nih.gov/pubmed/20864526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.165480
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