BRAF Drives Synovial Fibroblast Transformation in Rheumatoid Arthritis

Synovial fibroblasts destroy articular cartilage and bone in rheumatoid arthritis, but the mechanism of fibroblast transformation remains elusive. Because gain-of-function mutations of BRAF can transform fibroblasts, we examined BRAF in rheumatoid synovial fibroblasts. The strong gain-of-function mu...

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Autors principals: Weisbart, Richard H., Chan, Grace, Heinze, Emil, Mory, Rachel, Nishimura, Robert N., Colburn, Keith
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
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Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966042/
https://ncbi.nlm.nih.gov/pubmed/20843808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.168195
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