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BRAF Drives Synovial Fibroblast Transformation in Rheumatoid Arthritis
Synovial fibroblasts destroy articular cartilage and bone in rheumatoid arthritis, but the mechanism of fibroblast transformation remains elusive. Because gain-of-function mutations of BRAF can transform fibroblasts, we examined BRAF in rheumatoid synovial fibroblasts. The strong gain-of-function mu...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2966042/ https://ncbi.nlm.nih.gov/pubmed/20843808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.168195 |
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