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Mutations within the S4–S5 Linker Alter Voltage Sensor Constraints in hERG K(+) Channels
Human ether-a-go-go related gene (hERG) channel gating is associated with slow activation, yet the mechanistic basis for this is unclear. Here, we examine the effects of mutation of a unique glycine residue (G546) in the S4–S5 linker on voltage sensor movement and its coupling to pore gating. Substi...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Biophysical Society
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2965951/ https://ncbi.nlm.nih.gov/pubmed/21044581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.08.030 |
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