Mutations within the S4–S5 Linker Alter Voltage Sensor Constraints in hERG K(+) Channels

Human ether-a-go-go related gene (hERG) channel gating is associated with slow activation, yet the mechanistic basis for this is unclear. Here, we examine the effects of mutation of a unique glycine residue (G546) in the S4–S5 linker on voltage sensor movement and its coupling to pore gating. Substi...

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Main Authors: Van Slyke, Aaron C., Rezazadeh, Saman, Snopkowski, Mischa, Shi, Patrick, Allard, Charlene R., Claydon, Tom W.
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2010
Teme:
Channels and Transporters
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965951/
https://ncbi.nlm.nih.gov/pubmed/21044581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.08.030
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