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Cell Type–dependent Requirement for PIP Box–regulated Cdt1 Destruction During S Phase
DNA synthesis–coupled proteolysis of the prereplicative complex component Cdt1 by the CRL4(Cdt2) E3 ubiquitin ligase is thought to help prevent rereplication of the genome during S phase. To directly test whether CRL4(Cdt2)-triggered destruction of Cdt1 is required for normal cell cycle progression...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2965682/ https://ncbi.nlm.nih.gov/pubmed/20826610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-02-0130 |
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