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Cysteine 351 is an Essential Nucleophile in Catalysis by Porphyromonas gingivalis Peptidylarginine Deiminase
Peptidylarginine deiminase (PAD), which catalyzes the deimination of the guanidino group from peptidylarginine residues, belongs to a superfamily of guanidino-group modifying enzymes that have been shown to produce an S-alkylthiouronium ion intermediate during catalysis. Thiol-directed reagents iodo...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2965305/ https://ncbi.nlm.nih.gov/pubmed/20850413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.09.008 |
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