Development of an LC-MS/MS assay to determine plasma pharmacokinetics of the radioprotectant octadecyl thiophosphate (OTP) in monkeys

Octadecenyl thiophosphate (OTP), a synthetic analog of the lysophospholipid growth factor lysophosphatidic acid (LPA), significantly reduces mortality following a lethal dose of LD(80/30) radiation exposure in a mouse model of whole-body irradiation. To facilitate dose scaling between species, we de...

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Autors principals: Kosanam, Hari, Ma, Fei, He, Hui, Ramagiri, Suma, Gududuru, Veeresa, Tigyi, Gabor J., Van Rompay, Koen, Miller, Duane D., Yates, Charles R.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965032/
https://ncbi.nlm.nih.gov/pubmed/20719582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2010.07.004
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