Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

Chronic kidney disease is a leading cause of death in the United States. Tubulointerstitial fibrosis (TIF) is considered the final common pathway leading to end-stage renal disease (ESRD). Here, we used pharmacologic, genetic, in vivo, and in vitro experiments to show that activation of the Notch pa...

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Autores principales: Bielesz, Bernhard, Sirin, Yasemin, Si, Han, Niranjan, Thiruvur, Gruenwald, Antje, Ahn, Seonho, Kato, Hideki, Pullman, James, Gessler, Manfred, Haase, Volker H., Susztak, Katalin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964979/
https://ncbi.nlm.nih.gov/pubmed/20978353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43025
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