Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate: Implications into the Role of the Complex in Neurodegenerative Diseases

Decreased activity of the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDHC) in brain accompanies neurodegenerative diseases. To reveal molecular mechanisms of this association, we treated rats with a specific inhibitor of OGDHC, succinyl phosphonate, or exposed them to hypoxic stress. In ma...

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Detalhes bibliográficos
Main Authors: Trofimova, L., Lovat, M., Groznaya, A., Efimova, E., Dunaeva, T., Maslova, M., Graf, A., Bunik, V.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964918/
https://ncbi.nlm.nih.gov/pubmed/21049004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2010/749061
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