Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.

The mechanisms by which bone resorbing osteoclasts form and are activated by hormones are poorly understood. We show here that the generation of oxygen-derived free radicals in cultured bone is associated with the formation of new osteoclasts and enhanced bone resorption, identical to the effects se...

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Bibliografische Detailangaben

Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Garrett, I R, Boyce, B F, Oreffo, R O, Bonewald, L, Poser, J, Mundy, G R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296476/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2312718/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114485
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